Chinese scientists develop non-hallucinogenic antidepressant compounds

Chinese scientists developed two compounds that can relieve depression without causing hallucination [CGTN-CFP]
Chinese scientists develope compounds relieve depression without hallucination [CGTN]
CGTN | 24-Jan-2022

Chinese scientists designed two new compounds that can relieve depression but do not cause the unwanted effect of hallucination. Scientists from the Center for Excellence in Molecular Cell Science under the Chinese Academy of Sciences (CAS) and ShanghaiTech University mapped out the crystal structure of psilocybin, an FDA-approved breakthrough antidepressant medicine, when it is bonded with its receptors in the brain called serotonin 2A.

Then, they found a previously unknown binding place of psilocybin and its receptors. A further study showed that the new binding, regulated by lipids and serotonin, is linked with an antidepressant pathway that does not cause hallucinations, according to the study published Friday in the journal Science.